The prospect of pluripotent stem cells for diabetes mellitus treatment

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Abstract


Treatment options are limited for many diseases including diabetes, cancer and neurological and, many patients do not receive adequate therapy. New chemical entities largely developed within the BioPharma industry are not sufficient to satisfy patient’s needs. New gene and modified cell constructs were developed in academia and are expected on the market recently. This review presents describes somatic cells reprogramming technology and its application for the new drug development. We then summarize the progress made in genome editing and its application to cure monogenic hereditary disorders of the endocrine system.


Alexandra V. Panova

Vavilov Institute of General Genetics RAS

Email: panova@vigg.ru
SPIN-code: 9871-3456

Russian Federation, 3, Gubkin street, Moscow, 119991

Daria V. Goliudsova

Vavilov Institute of General Genetics RAS

Email: d.goliusova@gmail.com
SPIN-code: 9543-3453

Russian Federation, 3, Gubkin street, Moscow, 119991

Sergey L. Kiselev

Vavilov Institute of General Genetics RAS; Endocrinology Research Centre

Author for correspondence.
Email: kiselev@vigg.ru
ORCID iD: 0000-0001-7921-6987

Russian Federation, 3, Gubkin street, Moscow, 119991; 11, Dm. Ulyanova street, Moscow, 117036

PhD, Professor

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